Real-time Learning and Planning in Environments with Swarms:A Hierarchical and a Parameter-based Simulation Approach

Swarms can be applied in many relevant domains, such as patrolling or rescue. They usually follow simple local rules, leading to complex emergent behavior. Given their wide applicability, an agent may need to take decisions in an environment containing a swarm that is not under its control, and that may even be an antagonist. Predicting the behavior of each swarm member is a great challenge, and must be done under real time constraints, since they usually move constantly following quick reactive algorithms. We propose the first two solutions for this novel problem, showing integrated on-line learning and planning for decision-making with unknown swarms: (i) we learn an ellipse abstraction of the swarm based on statistical models, and predict its future parameters using time-series; (ii) we learn algorithm parameters followed by each swarm member, in order to directly simulate them. We find in our experiments that we are significantly faster to reach an objective than local repulsive forces, at the cost of success rate in some situations. Additionally, we show that this is a challenging problem for reinforcement learning

The reliability of the Basu Earnings conservatism metric, with particular reference to its association with auditor quality

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Litigation Risk and Auditor Conservatism: A UK-US Comparison

This paper investigates the association between auditor quality and the level of conservatism in reported earnings. Prior work has suggested auditor conservatism is influenced by auditors’ desire to prevent litigation and/or incurring reputational costs. To tease out the relative importance of the litigation versus reputational concerns of large audit firms as reasons for greater auditor conservatism, we conduct a comparative study for UK and US firms. In contrast to the US, the UK is a comparatively low litigation environment. Our results show that (1) large auditors are not associated with greater conservatism after the clients’ level of financial distress has been taken into account in the two countries; (2) the client profiles of large and small audit firms differ in key dimensions and these play a significant role in determining the incremental influence of audit firm size on the earnings conservatism of their clients. Therefore, rather than auditor quality driving the level of earnings conservatism, it appears to be the case that it is the underlying client characteristics which dictate the level of auditor conservatism. Failure to allow for such differences can result in misleading inferences being drawn about the effects of audit firm size on earnings conservatism

Additional file 1: Table S1. of The long non-coding RNA TP73-AS1 modulates HCC cell proliferation through miR-200a-dependent HMGB1/RAGE regulation

Sequence of primers. (DOCX 17 kb

Evaluation of droplet digital PCR rapid detection method and precise diagnosis and treatment for suspected sepsis (PROGRESS): a study protocol for a multi-center pragmatic randomized controlled trial

Abstract Background Sepsis is still a major public health concern and a medical emergency due to its high morbidity and mortality. Accurate and timely etiology diagnosis is crucial for sepsis management. As an emerging rapid and sensitive pathogen detection tool, digital droplet PCR (ddPCR) has shown promising potential in rapid identification of pathogens and antimicrobial resistance genes. However, the diagnostic value and clinical impact of ddPCR tests remains to be studied in patients with suspected sepsis. PROGRESS trial is aimed to evaluate the clinical effectiveness of a novel ddPCR assay compared with standard practice. Methods PROGRESS is a multicenter, open-label, pragmatic randomized controlled trial (pRCT) set in ten hospitals, including departments of infectious disease and intensive care units. In this study, a total of 2292 patients with suspected sepsis will be randomly assigned to two arms: the ddPCR group and the control group with a ratio of 3:1. The primary outcome is the diagnostic efficacy, that is, the sensitivity and specificity of the ddPCR assay compared with the synchronous blood culture. Secondary outcomes include the mortality rates and the mean Sequential Organ Failure Assessment (SOFA) score at follow-up time points, the length of stay in the hospital, the time to directed antimicrobial therapy, duration of broad-spectrum antibiotic use, and the EQ-5D-5L score on day 90. Discussion It is the first multicenter pragmatic RCT to explore the diagnostic efficacy and clinical impact of the ddPCR assay in patients with suspected sepsis, taking advantage of both RCT’s ability to establish causality and the feasibility of pragmatic approaches in real-world studies (RWS). This trial will help us to get a comprehensive view of the assay’s capacity for precise diagnosis and treatment of sepsis. It has the potential to monitor the pathogen load change and to guide the antimicrobial therapy, making a beneficial impact on the prognosis of sepsis patients. Trial registration: ClinicalTrial.gov, NCT05190861. Registered January 13, 2022—‘Retrospectively registered’, https://clinicaltrials.gov/ct2/show/NCT05190861